Efficacy and safety of multisession gamma knife surgery for benign orbital tumor

Kyung Il Jo1, Yong Seok Lim2, Doo Sik Kong2, Ho Jun Seol2, Do Hyun Nam2, Yoon Duck Kim3, Jung Il Lee2

1Seoul, Korea, Republic Of 2Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University Scho 3Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University Sch

Keywords: gamma knife, radiosurgery, meningioma, orbit, vision

Interactive Manuscript

Ask Questions of this Manuscript:



     Techniques, patient selection, and dose-selection remain important issues in the management of orbital tumors.
The goal of this study was to investigate safety and efficacy of multisession gamma knife radiosurgery (GKS) for benign orbital tumors.
     Thirty patients with benign orbital tumors (14 meningiomas, 10 cavernous hemangiomas, 4 schwannomas, 1solitary fibrous tumor and 1 granular cell tumor) were treated with GKS. Among them twenty-four patients with remained vision and tumors touching the optic nerve were treated with multisession (3 or 4 fractions) radiosurgery.
      The mean tumor volume was 3,506 mm3 (211–10,800). Median cumulative marginal dose was 20Gy (15–22) in multisession radiosurgery.
     After a mean follow-up of 25 months (range, 5–74 months), tumor control was confirmed in 22 out of 24 patients. In particular, cavernous hemangioma group(n=7) showed high tumor shrinkage rate (mean 53.7%, range 21.7~90%) during follow up periods (mean 23 months, range 13-38). Of the 24 patients whose preoperative vision was preserved, 12 patients showed improvement in visual acuity and/or visual field, and 12 patients showed stable visual acuity. No adverse events were noted during and after the GKS. None of the patients experienced radiation related morbidity.
     This was a retrospective study.
     GKS provides an effective management strategy in patients with benign orbital tumors. Besides classical single session radiosurgery multisession radiosurgery using Gamma knife may be a good strategy for tumors in direct contact with optic nerve. 
     Up to 20 Gy of cumulative marginal dose in 4 sessions is safe for preservation of visual function with high probability of tumor control.


Project Roles:

K. Jo (), Y. Lim (), D. Kong (), H. Seol (), D. Nam (), Y. Kim (), J. Lee ()