Gamma Knife Radiosurgery for intraventricular tumors

Xiaomin Liu, MD, PhD1, Yipei Zhang2, Zhiyuan Zhang2, Yanhe Li2, Dong Liu3, Qiang Jia2, Yiguang Lin2, Desheng Xu2

1Department of Neurosurgery and Gamma Knife Center, 2ND Hospital of Tianjin Medical University 2Gamma Knife Center, 2nd Hospital of Tianjin Medical University, Tianjin China 3Tianjin, China

Keywords: gamma knife, intraventricular tumor, brain tumor, outcome, radiosurgery

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     Intraventricular tumors can be managed in a variety of ways.
Our purpose was to evaluate the efficacy of Gamma knife radiosurgery for intraventricular tumors.
     From September 1995 to December 2007, 24 patients (male/female: 14/10) were treated with Gamma Knife radiosurgery for their intraventricular tumors. There were nine meningiomas, five choroid plexus papillomas, four ependymomas, three astrocytomas and three central neurocytomas. The diagnoses in 13 patients were confirmed by subtotal resection or biopsy and the other 11 patients were diagnosed by MRI imaging.
     Tumor locations included trigone of the lateral ventricle (9), body of the lateral cerebral ventricle (6), fourth ventricle (4), anterior horn of the lateral ventricle (3) and posterior horn of the lateral ventricle (2). The median tumor volume was 2.7 cm3 (range, 0.6-13.3). Median marginal dose was 16Gy (range, 8-18).
     After a median follow-up period of 37 months (6–84), imaging defined tumor control was achieved in 19 (79.2%) patients (11 had tumor regression). In five patients the tumor enlarged during follow-up period. Seven patients showed improvement in clinical manifestation while 10 patients showed no change. Two patients experienced transient headache after treatment which was cured by administration of steroid. Five patients with tumor progression showed progressive clinical deterioration.
     This was a retrospective study.
     Gamma knife radiosurgery is an effective adjunctive treatment option for residual or recurrent intraventricular tumors. 
     Patients who are unsuitable for resection can choose gamma knife as primary treatment for their small intraventricular tumors.


Project Roles:

X. Liu (), Y. Zhang (), Z. Zhang (), Y. Li (), D. Liu (), Q. Jia (), Y. Lin (), D. Xu ()