Gamma Knife stereotactic radiosurgery for atypical or anaplastic meningiomasYoshimasa Mori1, Tatsuya Koayashi2, Takahiko Tsugawa3, Chisa Hashizume2, Yuta Shibamoto41 2Nagoya Radiosurgery Center, Nagoya Kyoritsu Hospital 3Nagoya, Japan 4Department of Radiology Oncology, Nagoya City University Graduate School of Med Keywords: meningioma, gamma knife, brain tumor, malignant meningioma, outcome
Higher grade meningiomas pose unique clinical challenges.
We reported the results of Gamma Knife stereotactic radiosurgery (GKS) for recurrent of residual WHO grade 2 and 3 meningiomas after surgical resection. ‘Not benign’ meningioma has tendency to relapse repeatedly.
The mean age was 64 years (range, 30 - 80). All patients had had surgical resection and 10 patients had received conventional external-beam radiotherapy before GKS.
We treated 30 cases (13 males and 17 females) of WHO grade 2 or 3 meningioma by GKS. Total number of GKS procedure was 88 for all 30 patients (1 to 10 times for each patient).
Median follow-up time of 22 months (range, 5 – 225 months) was obtained for 20 among 30 patients. Eighteen patients among 20 were alive at the end of the follow-up time, though surgical resection was performed again in 4 patients and stereotactic radiotherapy was done in 3. Only 2 patients out of 20 died during the follow-up time. Only one patient in those two died from the brain tumor 91 month after GKS, and the other patient died from lung cancer 17 month after GKS.
This was a retrospective review.
Atypical and malignant meningioma is liable to relapse repeatedly.
Patients may survive longer with timely assessment including repeat GKS. Project Roles:
Y. Mori (), T. Koayashi (), T. Tsugawa (), C. Hashizume (), Y. Shibamoto ()