Gamma-knife Radiosurgery for Type 2 Neurofibromatosis Vestibular Schwannomas

Mooseong Kim1, Seonghwa Paeng2, Seyoung Pyo Yongtae2, Jung Younggun Jeong2, Sunil Lee2, Seongtae Kim2

1 2Inje University Busan Paik Hospital

Keywords: vestibular schwannoma, neurofibromatosis Type 2, gamma knife, radiosurgery, outcome

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     The goal of radiosurgery is to arrest tumor growth while preserving neurological function. Patients with vestibular schwannomas associated with neurofibromatosis type 2 represent a special challenge because of the risk of complete deafness. 
     Our goal was to evaluate the result of stereotactic radiosurgery treating vestibular schwannomas secondary to type 2 neurofibromatosis.
     10 patients underwent Gamma knife radiosurgery. 9 patients underwent one stage radiosurgery, one patient performed two stage radiosurgery.
     The mean tumor volume at radiosurgery was 13.3 ml, the mean marginal dose was 10.8 Gy (range 10-12 Gy)
     During the mean follow-up period of 54.7 months, 5 tumors (50%) regressed, 2 tumor (20%) remained unchanged, and One patient (10%) grew. New tumor was developed, and repeated radiosurgery was performed in two patients (20%) after radiosurgery. Useful hearing was preserved in 8(80%) of the patients. Facial nerve function was preserved in the all patients.
     This was a retrospective review.
     Radiosurgery is a valuable minimally invasive treatment for vestibular schwannomas secondary to type 2 neurofibromatosis. 
     A larger clinical experience will be important for further analysis.


Project Roles:

M. Kim (), S. Paeng (), S. Pyo Yongtae (), J. Younggun Jeong (), S. Lee (), S. Kim ()