Gamma knife therapy for cavernous hemangiomas of the cavernous sinus: clinical outcome of 39 patients.Peng Li1, Haibo Ren21 2Department of neurosurgery, West China Hospital of Sichuan University Keywords: cavernous hemangioma, gamma knife, cavernous sinus, radiosurgery, outcome
Cavernous hemangiomas can be managed in a number of ways.
A retrospective study was carried out to evaluate the efficacy and
safety of gamma knife (GK) for cavernous hemangiomas of the cavernous
From July 2004 to March 2010, forty-two patients with CHCS underwent
gamma knife therapy at West China Hospital of Sichuan University. Among
these patients, 38 patients underwent GK as the initial treatment; the
other 4 cases had GK treatment after microsurgery. An average
prescription dose was 13.3Gy (12-15Gy) at 47.9% (40-50%) isodose line.
All patients were followed-up by periodical enhanced MRI scan and
The improvement of clinical symptoms and tumor control were analyzed.
Thirty-nine patients accomplished follow-up with a mean duration of 38.4 months. Complete tumor remission (tumor size decreased more than 90%) was observed in 7 patients. Twenty-eight patients had significant tumor control (tumor size decreased more than 30%). No significant change in tumor size was reported in 4 patients. Clinical symptoms were reported including headache (33 cases), facial numbness (19 cases), facial pain (14 cases) and diplopia (6 cases). Significant improvement in headache, facial numbness, facial pain and diplopia was reported in 27, 11, 11 and 5 patients respectively. No newly developed cranial nerve damages were observed.
This was a retrospective study.
The preliminary result indicated that GK might be an effective and safe option for CHCS management.
Long term follow-up and more cases are needed to investigate the advantage and disadvantage of this management. Project Roles:
P. Li (), H. Ren ()