An investigation of eye lens dose of stereotactic radiosurgery for benign brain tumor using Leksell gamma knife model CCheng-Loong Liang1, D.K Chiu2, T.B Chen3, K Lu2, P.C Liliang2, H.J Chen21Kaohsiung, Taiwan 2Department of Neurosurgery, E-Da Hospital, I-Shou University, Taiwan 3Department of Medical Imaging and Radiological Sciences, I-Shou University, Kaohsiung, Taiwan Keywords: brain tumor, radiation, cataract, cornea, gamma knife
The eye lens dose may be important in radiosurgical planning.
The authors conducted a study to assess the eye lens dosimetry in benign
brain tumor treatment when using the Leksell gamma knife model C.
Fifty consecutive patients with benign brain tumor underwent gamma knife
radiosurgery (GKRS) were evaluated with the Leksell GammaPlan system.
The ages, gender, use of plugs, numbers of plugs, tumor volume, distances from tumor to lens, side of lens, treatment time, prescription doses, and numbers of isocenters were evaluated. The ANOCOVA (Analysis of Covariance) was applied to build a predicted equation and test significant predictors
The ages, gender, numbers of plugs, side of lens, treatment time, and numbers of isocenters were not significant predictors. The tumor volume (P=0.003), use of plugs (P<0.001), prescription doses (P=0.039), and distance from tumor to lens (P=0.001) were significant predictors to build an equation of maximum dose of eyes lens in the model (R2=0.812).
This was a retrospective study.
Patients with benign brain tumors undergoing GKRS without eye shielding may develop cataracts due to the high radiation dose to the eye lenses.
The authors suggest the routine use of bilateral eye shielding for the
patients with benign brain tumors especial for the larger size of
tumors, higher prescription doses and tumor location near the eye lens. Project Roles:
C. Liang (), D. Chiu (), T. Chen (), K. Lu (), P. Liliang (), H. Chen ()