The enlargement of nonfunctional pituitary adenomas after postoperative gamma knife radiosurgery is the consequence of hypothyroidism.Keywords: pituitary adenoma, gamma knife, hormone dysfunction, outcome, radiosurgeryInteractive Manuscript
Ask Questions of this Manuscript:
What is the background behind your study?
Tumor enlargement after pituitary radiosurgery can be due to several outcomes.
What is the purpose of your study?
Our purpose was to evaluate the tumor control failure of nonfunctional pituitary adenomas associate with hypopituitarism after postoperative gamma knife radiosurgery.
Describe your patient group.
The median duration of follow up for the 67 patients after GKR was 38 months.
Describe what you did.
The endocrine and image follow-up data of sixty-seven patients with residual or recurrence nonfunctional pituitary adenoma after operation treated with GKR between 2006 and 2009 were studied.
Describe your main findings.
The tumor control rate was 94%. New hormone deficiency after GKR was found in seven patients(10%). Six patients (9%) developed hypothyroidism and three patients (4%) developed cortisol deficiency. Four cases were found with enlargement of pituitary adenomas and new hypothyroidism. The median follow-up time of patients with new hormone deficiency after GKR was 47 months. Using Sodiumlevothyroxine(Euthyrox) as the replace treatment for the new hypopituitarism patients decreased the tumor volume which was found enlargement on the follow-up images without retreatment using GKR.
Describe the main limitation of this study.
This was a retrospective study.
Describe your main conclusion.
Gamma Knife is a safe and effective treatment for residual or recurrent nonfunctional pituitary adenomas. The enlargement of nonfunctional pituitary adenomas after GKR is the consequence of hypothyroidism and is not the failure outcome of GKR.
Describe the importance of your findings and how they can be used by others.
Replacement therapyusing Euthyrox for hypothyroidism is effective in decreasing the enlargement tumor volume than retreatment using GKR.
Tumor enlargement after pituitary radiosurgery can be due to several outcomes.
Our purpose was to evaluate the tumor control failure of nonfunctional pituitary adenomas associate with hypopituitarism after postoperative gamma knife radiosurgery.
The median duration of follow up for the 67 patients after GKR was 38 months.
The endocrine and image follow-up data of sixty-seven patients with residual or recurrence nonfunctional pituitary adenoma after operation treated with GKR between 2006 and 2009 were studied.
The tumor control rate was 94%. New hormone deficiency after GKR was found in seven patients(10%). Six patients (9%) developed hypothyroidism and three patients (4%) developed cortisol deficiency. Four cases were found with enlargement of pituitary adenomas and new hypothyroidism. The median follow-up time of patients with new hormone deficiency after GKR was 47 months. Using Sodiumlevothyroxine(Euthyrox) as the replace treatment for the new hypopituitarism patients decreased the tumor volume which was found enlargement on the follow-up images without retreatment using GKR.
This was a retrospective study.
Gamma Knife is a safe and effective treatment for residual or recurrent nonfunctional pituitary adenomas. The enlargement of nonfunctional pituitary adenomas after GKR is the consequence of hypothyroidism and is not the failure outcome of GKR.
Replacement therapyusing Euthyrox for hypothyroidism is effective in decreasing the enlargement tumor volume than retreatment using GKR.
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