GKS for Neurofibromatosis type 2Keywords: neurofibromatosis Type 2, hearing function, vestibular schwannoma, gamma knife, outcomeInteractive Manuscript
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What is the background behind your study?
The goal of radiosurgery is to arrest tumor growth while preserving neurological function. Patients with vestibular schwannomas associated with neurofibromatosis type 2 represent a special challenge because of the risk of complete deafness.
What is the purpose of your study?
Our purpose was to evaluate the result of stereotactic radiosurgery treating vestibular schwannomas secondary to type 2 neurofibromatosis.
Describe your patient group.
10 patients underwent Gamma knife radiosurgery. 9 patients underwent one
stage radiosurgery, one patient performed two stage radiosurgery.
Describe what you did.
The mean tumor volume at radiosurgery was 13.3 ml, the mean marginal dose was 10.8 Gy (range 10-12 Gy)
Describe your main findings.
During the mean follow-up period of 54.7 months, 5 tumors (50%) regressed, 2 tumor (20%) remained unchanged, and One patient (10%) grew. New tumor was developed, and repeated radiosurgery was performed in two patients (20%) after radiosurgery. Useful hearing was preserved in 8 (80%) of the patients. Facial nerve function was preserved in the all patients.
Describe the main limitation of this study.
This was a retrospective study.
Describe your main conclusion.
Radiosurgery is a valuable minimally invasive treatment for vestibular schwannomas secondary to type 2 neurofibromatosis.
Describe the importance of your findings and how they can be used by others.
Hearing preservation results will have to be studied over time to test durability.
The goal of radiosurgery is to arrest tumor growth while preserving neurological function. Patients with vestibular schwannomas associated with neurofibromatosis type 2 represent a special challenge because of the risk of complete deafness.
Our purpose was to evaluate the result of stereotactic radiosurgery treating vestibular schwannomas secondary to type 2 neurofibromatosis.
10 patients underwent Gamma knife radiosurgery. 9 patients underwent one
stage radiosurgery, one patient performed two stage radiosurgery.
The mean tumor volume at radiosurgery was 13.3 ml, the mean marginal dose was 10.8 Gy (range 10-12 Gy)
During the mean follow-up period of 54.7 months, 5 tumors (50%) regressed, 2 tumor (20%) remained unchanged, and One patient (10%) grew. New tumor was developed, and repeated radiosurgery was performed in two patients (20%) after radiosurgery. Useful hearing was preserved in 8 (80%) of the patients. Facial nerve function was preserved in the all patients.
This was a retrospective study.
Radiosurgery is a valuable minimally invasive treatment for vestibular schwannomas secondary to type 2 neurofibromatosis.
Hearing preservation results will have to be studied over time to test durability.
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