GKS for Neurofibromatosis type 2

Keywords: neurofibromatosis Type 2, hearing function, vestibular schwannoma, gamma knife, outcome

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     The goal of radiosurgery is to arrest tumor growth while preserving neurological function. Patients with vestibular schwannomas associated with neurofibromatosis type 2 represent a special challenge because of the risk of complete deafness.
     Our purpose was to evaluate the result of stereotactic radiosurgery treating vestibular schwannomas secondary to type 2 neurofibromatosis.
     10 patients underwent Gamma knife radiosurgery. 9 patients underwent one stage radiosurgery, one patient performed two stage radiosurgery.
      The mean tumor volume at radiosurgery was 13.3 ml, the mean marginal dose was 10.8 Gy (range 10-12 Gy)
     During the mean follow-up period of 54.7 months, 5 tumors (50%) regressed, 2 tumor (20%) remained unchanged, and One patient (10%) grew. New tumor was developed, and repeated radiosurgery was performed in two patients (20%) after radiosurgery. Useful hearing was preserved in 8 (80%) of the patients. Facial nerve function was preserved in the all patients.
     This was a retrospective study.
     Radiosurgery is a valuable minimally invasive treatment for vestibular schwannomas secondary to type 2 neurofibromatosis.
     Hearing preservation results will have to be studied over time to test durability.


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