Dosimetric Evaluation Of Fractionated Intracranial Radiation Therapy With Gamma Knife And Cyberknife

Keywords: gamma knife, dosimetry, cyberknife, Radiation Therapy, radiosurgery

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     To compare the difference in dose plan of intracranial radiation therapy between Gamma Knife and CyberKnife.
     Two patients with brain lesions of significant size were discussed for the options of radiation treatment of Gamma Knife versus CyberKnife.
     Traditionally, Gamma Knife is used exclusively for stereotactic radiosurgery (SRS) of single fraction treatment for brain lesions up to 4 cm in size. Recently, the manufacturer of Leksell Gamma Knife has unveiled the eXtend repositioning system, which could allow for fractionated stereotactic radiation therapy (SRT) of intracranial tumors on Gamma Knife Perfexion.
     It is evident in these cases that the Gamma Knife plan has produced the dose distribution conformal to the targets better than the CyberKnife plan. The lower isodose lines tend to spread far beyond the target area in the CyberKnife plan attributing to the energy, collimation and non-isocentricity of its beam. The critical structures in general receive less dosage in Gamma Knife than in CyberKnife.
     This is a retrospective study.
     Both CyberKnife and Gamma Knife can be used for stereotactic radiation treatment of intracranial tumors.
      The dose plan of this study shows that Gamma Knife may have some advantages over CyberKnife in dosimetry. When both modalities are available, the clinical decision should be made taking other factors into account.


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