Gamma Radiosurgery Induced Tumors In Two Patients With Neurofibromatosis 2Keywords: gamma knife, vestibular schwannoma, radiation-associated tumor, meningioma, complicationsInteractive Manuscript
Ask Questions of this Manuscript:
What is the background behind your study?
Radiation can lead to tumor formation.
What is the purpose of your study?
We are presenting our experience in two cases of neurofibromatosis II which were treated with Gamma radiosurgery.
Describe your patient group.
Both patients, a male and a female were 17 years of age at the time of presentation in 1996. Both presented with multiple intracranial and spinal tumors. The female patient harbored the following lesions : cortical meningioma, cavernous, sinus meningioma, bilateral acoustic neuroma, C1-C2 schwanoma, intramedullary thoracic spinal cord tumor. She presented with decreased hearing and tinnitus on left side and quadriparesis.
Describe what you did.
She was treated with surgical excision of a C1-C2 schwanoma and Gamma radiosurgery for her worst hearing side acoustic neuroma .
Describe your main findings.
Few years later she went on to develop huge atypical meningioma on top of her radiosurgically treated acoustic neuroma ( the meningioma was like onion leaves surrounding the core of acoustic neuroma) .
Describe the main limitation of this study.
This is a retrospective study.
Describe your main conclusion.
We raise the question " Are these lesions Gamma radiosurgery induced or are they part of the natural history of neurofibromatosis ? "
Describe the importance of your findings and how they can be used by others.
Radiation-associated tumors should be studied.
Radiation can lead to tumor formation.
We are presenting our experience in two cases of neurofibromatosis II which were treated with Gamma radiosurgery.
Both patients, a male and a female were 17 years of age at the time of presentation in 1996. Both presented with multiple intracranial and spinal tumors. The female patient harbored the following lesions : cortical meningioma, cavernous, sinus meningioma, bilateral acoustic neuroma, C1-C2 schwanoma, intramedullary thoracic spinal cord tumor. She presented with decreased hearing and tinnitus on left side and quadriparesis.
She was treated with surgical excision of a C1-C2 schwanoma and Gamma radiosurgery for her worst hearing side acoustic neuroma .
Few years later she went on to develop huge atypical meningioma on top of her radiosurgically treated acoustic neuroma ( the meningioma was like onion leaves surrounding the core of acoustic neuroma) .
This is a retrospective study.
We raise the question " Are these lesions Gamma radiosurgery induced or are they part of the natural history of neurofibromatosis ? "
Radiation-associated tumors should be studied.
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