Gamma Radiosurgery Induced Tumors In Two Patients With Neurofibromatosis 2

Ibrahim Sbeih1

1Ibn Alhytham Amman,Jordan

Keywords: gamma knife, vestibular schwannoma, radiation-associated tumor, meningioma, complications

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       Radiation can lead to tumor formation.
     We are presenting our experience in two cases of neurofibromatosis II which were treated with Gamma radiosurgery.
     Both patients, a male and a female were 17 years of age at the time of presentation in 1996. Both presented with multiple intracranial and spinal tumors. The female patient harbored the following lesions : cortical meningioma, cavernous, sinus meningioma, bilateral acoustic neuroma, C1-C2 schwanoma, intramedullary thoracic spinal cord tumor. She presented with decreased hearing and tinnitus on left side and quadriparesis.  
     She was treated with surgical excision of a C1-C2 schwanoma and Gamma radiosurgery for her worst hearing side acoustic neuroma .
     Few years later she went on to develop huge atypical meningioma on top of her radiosurgically treated acoustic neuroma ( the meningioma was like onion leaves surrounding the core of acoustic neuroma) .
       This is a retrospective study.
     We raise the question " Are these lesions Gamma radiosurgery induced  or are they part of the natural history of neurofibromatosis ? "
     Radiation-associated tumors should be studied.


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