Radiosurgery For Brain Metastasis From Advanced Gastric Cancer

Ho Jung Han1, Dong Gyu Kim1, Chang-Wan Oh1, Hyun-Tai Chung, PhD2, Sun Ha Paek1, Hee-Won Jung1

1Seoul National University Bundang Hospital, Gyeonggi-do, Rep. of Korea 2Seoul National University College of Medicine

Keywords: gastric cancer, outcome, brain metastasis, cancer, gamma knife

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Abstract

       Gastric cancer outcomes are less frequently reported than other cancer types.
     We retrospectively evaluated the survival of patients with brain metastases from advanced gastric cancer (AGC) after radiosurgery (RS).
     Between 1998 and 2007, a total of 11 patients (median age, 61 years; range, 36-70) were diagnosed with brain metastasis from AGC and treated with RS. Each of five (46%) patients had two brain metastases. The median volume of the 16 lesions was 2.9 cm3 (range, 0.1-33.8).
     The median marginal dose prescribed was 20 Gy (range, 10-25) at the 50% isodose line. RS was the primary treatment for brain metastases in six patients.
     As of Feb 28, 2008, 8 (73%) patients had died and three (27%) were living with stable disease. The median survival time was 17.0±3.9 months (95% CI, 9.4-24.6). The median progression-free survival time was 9.0±2.5 months (95% CI, 4.2-13.8). Patients who did not undergo WBRT died within eight months, and the other six patients treated with WBRT at various time intervals from diagnosis of brain metastases survived, with a median survival time of 19.0±3.4 months (95% CI, 12.4-25.6).
     This is a retrospective study.
     Radiosurgery seems to be a good alternative to surgical resection for patients with brain metastases from AGC, when performed in conjunction with WBRT.
     Although less common than other tumors, radiosurgery can be of value.


Acknowledgements

Project Roles:

H. Han (), D. Kim (), C. Oh (), H. Chung (), S. Paek (), H. Jung ()