Clinical Outcome Of Gamma Knife Radiosurgery For Cavernous Malformation

Keywords: gamma knife, outcome, cavernous malformation, radiosurgery, vascular malformation

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     The efficacy of gamma-knife radiosurgery (GKRS) for cavernous malformation (CM) is still controversial.
     We analyzed result of our series to find the efficiency of GKRS for CM.
     Between June 2006 and June 2008, 16 patients were included. Twelve patients experienced hemorrhagic event. One patient suffered from epilepsy. Three patients were incidentally diagnosed.
     Mean follow up duration was 38 months.
     Average volume was 1.96 (0.06~9.9)cc. Average numbers of isocenter were 6.12 (1~19). Average marginal dose were 15.625 (15~20) Gy. In period of first 3 months 2 patients showed rebleeding. In 6 months after GKRS two patients experienced adverse radiation effect. One patient showed radiation necrosis and the other one suffered from hemiparesis. The patient who showed radiation necrosis fully recovered but patient with hemiparesis still suffered from motor grade 4 hemiparesis. Other patients did not have bleeding or adverse radiation effect.
     This is a retrospective study.
     Although our follow up duration is relatively short, GKRS has the effectiveness of treatment for CM.
     Meticulous selection of marginal dose and highly matched conformity is necessary for good outcome.


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