Tumor Shrinkage Of Vestibular Schwannomas Treated With Gamma Knife Surgery: Results Of More Than 5 Years Follow-upKeywords: gamma knife, radiosurgery, vestibular schwannoma, outcome, brain tumorInteractive Manuscript
Ask Questions of this Manuscript:
What is the background behind your study?
What is the purpose of your study?
To review tumor shrinkage after gamma knife surgery (GKS) for vestibular schwannomas (VSs).
Describe your patient group.
Among 186 VS treated with GKS, 87 consecutive unilateral VS observed on follow-up MRI for at least 5 years were analyzed.
Describe what you did.
For each lesion the Gadolinium enhanced volume was measured serially every 3 months for 2 years and 6-12 months thereafter using GammaPlanTM or SurgiPlanTM. The frequency and degree of volume shrinkage were documented.
Describe your main findings.
There were 31 men and 56 women, with a mean age of 58.8, range 29 to 80, years. The tumor volume at GKS averaged 2.5 cc (0.1 -13.2 cc), and was irradiated with 50 (50-67) % 12 (10.5-13.0) Gy at the periphery. The mean observation period was 6.4 years (5.0-10.5). Peak volume expansion was most frequently observed at 6.4 post-GKS months and averaged 58% (0-613%). The mean volume shrinkage was 31% and 11 tumors were still larger than the initial volume at 5 years after GKS. The homogeneous enhanced tumors were related to less shrinkage.
Describe the main limitation of this study.
This is a retrospective study.
Describe your main conclusion.
MRI findings correlated with tumor shrinkage.
Describe the importance of your findings and how they can be used by others.
Most VS showed shrinkage at 5 years after GKS. The mean volume shrinkage was 31%.
To review tumor shrinkage after gamma knife surgery (GKS) for vestibular schwannomas (VSs).
Among 186 VS treated with GKS, 87 consecutive unilateral VS observed on follow-up MRI for at least 5 years were analyzed.
For each lesion the Gadolinium enhanced volume was measured serially every 3 months for 2 years and 6-12 months thereafter using GammaPlanTM or SurgiPlanTM. The frequency and degree of volume shrinkage were documented.
There were 31 men and 56 women, with a mean age of 58.8, range 29 to 80, years. The tumor volume at GKS averaged 2.5 cc (0.1 -13.2 cc), and was irradiated with 50 (50-67) % 12 (10.5-13.0) Gy at the periphery. The mean observation period was 6.4 years (5.0-10.5). Peak volume expansion was most frequently observed at 6.4 post-GKS months and averaged 58% (0-613%). The mean volume shrinkage was 31% and 11 tumors were still larger than the initial volume at 5 years after GKS. The homogeneous enhanced tumors were related to less shrinkage.
This is a retrospective study.
MRI findings correlated with tumor shrinkage.
Most VS showed shrinkage at 5 years after GKS. The mean volume shrinkage was 31%.
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