Gamma Knife Radiosurgery For Cushing DiseaseMariko Nagai11Tokyo Womens Medical University, Tokyo, Japan Keywords: Cushing's disease, pituitary adenoma, gamma knife, outcome, hormone dysfunctionInteractive Manuscript
Ask Questions of this Manuscript:
What is the background behind your study?
More than 20,000 pituitary adenomas have already been treated by Gamma Knife Surgery (GKS) worldwide. Among them, most difficult type is one which invades the cavernous sinus.
What is the purpose of your study?
We report some of the cases treated by our original method.
Describe your patient group.
Since December 2001 to May 2009, 17 patients with ACTH producing tumors were treated at our institute. 4 of them experienced repeat GKS.
Describe what you did.
At treatment, constructive interference in steady state with gadolinium was used for MRI to achieve clear visualization of the tumors and critical surrounding structures. Average dose of 26.6 Gy (range: 12-35 Gy) was used.
Describe your main findings.
The average follow-up was 34.8 months (range: 6-78). Tumor volume control rate was 100% and shrinkage rate was 71.4%. Hormonal normalization rate was 50%, and improvement was observed in 42.9%. Two patients experienced complications; one had oculomotor palsy and the other had abducent palsy.
Describe the main limitation of this study.
This is a retrospective study.
Describe your main conclusion.
It is possible to control not only the tumor volume.
Describe the importance of your findings and how they can be used by others.
It is possible to also decrease the volume and normalize hormonal condition by keeping high intratumoral isodose.
More than 20,000 pituitary adenomas have already been treated by Gamma Knife Surgery (GKS) worldwide. Among them, most difficult type is one which invades the cavernous sinus.
We report some of the cases treated by our original method.
Since December 2001 to May 2009, 17 patients with ACTH producing tumors were treated at our institute. 4 of them experienced repeat GKS.
At treatment, constructive interference in steady state with gadolinium was used for MRI to achieve clear visualization of the tumors and critical surrounding structures. Average dose of 26.6 Gy (range: 12-35 Gy) was used.
The average follow-up was 34.8 months (range: 6-78). Tumor volume control rate was 100% and shrinkage rate was 71.4%. Hormonal normalization rate was 50%, and improvement was observed in 42.9%. Two patients experienced complications; one had oculomotor palsy and the other had abducent palsy.
This is a retrospective study.
It is possible to control not only the tumor volume.
It is possible to also decrease the volume and normalize hormonal condition by keeping high intratumoral isodose.
Project Roles:
M. Nagai ()
