5 Years Result Of Radio Surgery For Cushing Diseases In IranKeywords: pituitary adenoma, gamma knife, Cushing's disease, radiosurgery, outcomeInteractive Manuscript
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What is the background behind your study?
Cushing Diseases is a serious endocrinopathy that if left untreated will be associated with significant morbidity rates. Even in the hands of an experienced neurosurgeon, some patients may not achieve remission after transsphenoidal resection of the adenoma. Gamma Knife radiosurgery (GKRS) is usually reserved as a second line treatment following an initial, unsuccessful attempt at a microsurgical cure.
What is the purpose of your study?
The goals of stereotactic radiosurgery in the treatment of Cushing’s disease pituitary tumors are to inactivate adenoma cells, controlling tumor growth and to normalize hormone overproduction. Ideally, these goals are met without damaging the residual normal pituitary gland and surrounding vascular and neuronal structures.
Describe your patient group.
In our institute 33 patients with Cushing''s diseases 29 patients had previous T.S approach 1 or 2 times.
Describe what you did.
The patients were treated by Gamma Knife radio Surgery during Jan 2003 to 2009 with mean follow up of 36 months . All of them were treated with 22-26Gy.
Describe your main findings.
26 patients (78%) were in remission after a mean 28 months (9-60m) follow up.
Describe the main limitation of this study.
This question was not answered by the author
Describe your main conclusion.
Gamma Knife radiosurgery represents a safe and predominantly effective treatment option for patients with recurrent or persistent Cushing’s disease following an initial resection.
Describe the importance of your findings and how they can be used by others.
Gamma Knife Radio Surgery especially as an adjunctive treatment to T.S surgery is an alternative to other therapeutic options in view of their adverse effect.
Cushing Diseases is a serious endocrinopathy that if left untreated will be associated with significant morbidity rates. Even in the hands of an experienced neurosurgeon, some patients may not achieve remission after transsphenoidal resection of the adenoma. Gamma Knife radiosurgery (GKRS) is usually reserved as a second line treatment following an initial, unsuccessful attempt at a microsurgical cure.
The goals of stereotactic radiosurgery in the treatment of Cushing’s disease pituitary tumors are to inactivate adenoma cells, controlling tumor growth and to normalize hormone overproduction. Ideally, these goals are met without damaging the residual normal pituitary gland and surrounding vascular and neuronal structures.
In our institute 33 patients with Cushing''s diseases 29 patients had previous T.S approach 1 or 2 times.
The patients were treated by Gamma Knife radio Surgery during Jan 2003 to 2009 with mean follow up of 36 months . All of them were treated with 22-26Gy.
26 patients (78%) were in remission after a mean 28 months (9-60m) follow up.
Gamma Knife radiosurgery represents a safe and predominantly effective treatment option for patients with recurrent or persistent Cushing’s disease following an initial resection.
Gamma Knife Radio Surgery especially as an adjunctive treatment to T.S surgery is an alternative to other therapeutic options in view of their adverse effect.
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