Gamma Knife Radiosurgery For Treatment Of TremorKeywords: tremor, essential tremor, gamma knife, outcome, Parkinson's DiseaseInteractive Manuscript
Ask Questions of this Manuscript:
What is the background behind your study?
What is the purpose of your study?
The purpose of this study was to investigate the effects of gamma knife thalamotomy for treatment of disabling tremor.
Describe your patient group.
Eleven patients underwent magnetic resonance imaging-guided radiosurgical nucleus ventralis intermedius (VIM) thalamotomy for the treatment of parkinsonian tremor (5 patients), essential tremor (5 patients), or MS tremor (one patient).
Describe what you did.
11 patients underwent magnetic resonance imaging-guided radiosurgical nucleus ventralis intermedius thalamotomy. A single isocenter exposure with the 4-mm collimator helmet was used to make the lesions.
Describe your main findings.
In 8 patients tremor disappeared totally and in 2 patients partially. In patient with MS no difference was observed. In 3 of the patients radiation related side effects were observed. All these patients had hemiparesis due to large necrosis in thalamus and edema in internal capsule. .Two of them were temporary and 1 of them was permanent.
Describe the main limitation of this study.
This is a retrospective study.
Describe your main conclusion.
Gamma knife VIM thalamotomy provides relief from tremor equivalent to that provided by radiofrequency thalamotomy or deep brain stimulation.
Describe the importance of your findings and how they can be used by others.
However its use should be limited to the patients with contrindications for surgery.
The purpose of this study was to investigate the effects of gamma knife thalamotomy for treatment of disabling tremor.
Eleven patients underwent magnetic resonance imaging-guided radiosurgical nucleus ventralis intermedius (VIM) thalamotomy for the treatment of parkinsonian tremor (5 patients), essential tremor (5 patients), or MS tremor (one patient).
11 patients underwent magnetic resonance imaging-guided radiosurgical nucleus ventralis intermedius thalamotomy. A single isocenter exposure with the 4-mm collimator helmet was used to make the lesions.
In 8 patients tremor disappeared totally and in 2 patients partially. In patient with MS no difference was observed. In 3 of the patients radiation related side effects were observed. All these patients had hemiparesis due to large necrosis in thalamus and edema in internal capsule. .Two of them were temporary and 1 of them was permanent.
This is a retrospective study.
Gamma knife VIM thalamotomy provides relief from tremor equivalent to that provided by radiofrequency thalamotomy or deep brain stimulation.
However its use should be limited to the patients with contrindications for surgery.
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