Ethanol Consumption And Its Association With The Development Of Peritumoral Edema After Radiosurgeryof Intracranial Meningiomas: A Retrospective Analysis.

Keywords: meningioma, radiation injury, gamma knife, outcome, complications

Interactive Manuscript

Ask Questions of this Manuscript:



     For this study, a retrospective analysis of several patient factors (medications, diabetes mellitus, tobacco and ethanol use) were reviewed to determine potential prognostic indicators related to peritumoral edema formation after Gamma Knife radiosurgery for intracranial meningiomas.
     There were 55 patients (39 females and 15 males). The mean follow-up time was 28.4 months (range 6 – 66 months). Patients were categorized into two groups. Group one: symptomatic edema requiring steroid treatment. Group two: patients who did not develop symptomatic edema or those with pre-existing, non-symptomatic edema.
     12 of the 55 patients (22%) required treatment for symptomatic edema and were placed into group one. 6 of 12 patients in this group experienced worsening of pre-existing edema while 6 of 12 developed a new onset of symptomatic edema. Of the 43 patients in group two, 64% (35 of 43) did not develop any edema while 14.5% (8 of 43) had pre-existing, non-symptomatic edema or developed a new onset of non-symptomatic edema. Medication use was divided into four general categories (anti-seizure, antihypertensive, statins, and aspirin/blood thinners).
     No relationship was found between the two groups and edema formation in regards to medications, use of tobacco products or diabetes. 50% (6 of 12) of patients in group one responded positive for ethanol use compared to 7% (3 of 43) of patients in group two. Consuming one or more beverages containing ethanol per day was considered positive for ETOH use.
     This is a retrospective study.
     A significant correlation between alcohol consumption and edema formation was found. Patients consuming at least one alcohol drink per day had a seven times greater likelihood of developing either pre or post-radiosurgery symptomatic peritumoral edema formation.
     Those responding positive for ETOH use were also more likely to be recalcitrant to steroid therapy. Additional research is needed, but the preliminary findings may prove to be beneficial in making recommendations to reduce symptomatic edema development.


Project Roles: