Transient Expansion Of Vestibular Schwannoma Following Gamma Knife Radiosurgery

Keywords: vestibular schwannoma, Imaging, gamma knife, outcome, recurrent disease

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     We assessed whether intratumoral microhemorrhage have reference to transient expansion of vestibular schwannoma following Gamma Knife Radiosurgery (GKRS) using T2*-weighted MR imaging.
     Seventy-one patients with unirateral vestibular schwannoma(VS) treated with GKRS were examined. MRI was performed with T2*-weighted gradient-echo in addition to enhanced T1WI before and serially after treatment.
     The frequency of transient tumor expansion was documented and correlation with intratumoral microhemorrhage was analyzed.
     Before GKRS, intratumoral microhemorrhage was revealed in 33/71 tumors. Transient expansion following GKRS found in 22/71 tumors. Intratumoral hemorrhages were detected in 15/22 tumors with transient expansion. And in 7 tumors, microhemorrhages increased simultaneously with transient tumor expansion.
     This is a retrospective study.
     Intratumoral microhemorrhage in VS was found to be frequent with using T2*-weighted MR imaging. And the transient expansion of VS following GKRS was reported to be more frequent than previous examinations. But the prognostic factors influencing transient tumor expansion was not revealed yet.
      In this examination, we suspected Intratumoral microhemorrhage is a possible mechanism of transient expansion of VS following GKRS.


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