A Prospective Analysis Of Quality Of Life Outcomes After Gamma Knife Radiosurgery For Brain MetastasesKeywords: brain metastasis, quality of life, gamma knife, outcome, radiosurgeryInteractive Manuscript
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What is the background behind your study?
What is the purpose of your study?
Evaluate the impact of Gamma Knife Radiosurgery (GKRS) on Quality of Life (QOL) using standardized questionnaire before and after GKRS correlating QOL with treatment characteristics.
Describe your patient group.
Brain metastases in 319 patients treated with GKRS alone or combined with whole brain radiotherapy (WBRT) (10/2008 – 10/2009) .Pre-GKRS QOLQ completed in 91 (28%) patients with 41 (45%) of those patients completing post-treatment QOLQ. At 3 months, 41 (16 male, 25 female) had completed QOLQ. At 6 months, 17 (10 male, 7 female) and at year, 6 (4 male, 2 female) had completed QOLQ. The median age 63 yrs (range: 32-90); median lesions/patient was 2(1-16).
Describe what you did.
A prospective evaluation using QOL questionnaires (QOLQ) at 3, 6, and year post-treatment. Mean total tumor volume was 2.03 cc (0.003-42), median KPS was 80 (30-100). 47 patients underwent GKRS alone (surgery or not) (Group IA-C); 7 GKRS then WBRT + surgery (Group II); 17 WBRT +GKRS (surgery or not) (Group IIIA, B). Addition of WBRT, chemotherapy, pre-GK KPS, number of lesions, maximum size and volume were analyzed for QOL effect.
Describe your main findings.
The results were submitted as a table that is impossible to format for the abstract.
Describe the main limitation of this study.
This is a retrospective study.
Describe your main conclusion.
Group IA does better but declines at a year; Group IB has better QOL. In Group II patients are better in first 3 months. In Group III, patients having surgery + WB +GK improve while WB +GK decline.
Describe the importance of your findings and how they can be used by others.
Clearly, a larger patient population and more follow-up are needed.
Evaluate the impact of Gamma Knife Radiosurgery (GKRS) on Quality of Life (QOL) using standardized questionnaire before and after GKRS correlating QOL with treatment characteristics.
Brain metastases in 319 patients treated with GKRS alone or combined with whole brain radiotherapy (WBRT) (10/2008 – 10/2009) .Pre-GKRS QOLQ completed in 91 (28%) patients with 41 (45%) of those patients completing post-treatment QOLQ. At 3 months, 41 (16 male, 25 female) had completed QOLQ. At 6 months, 17 (10 male, 7 female) and at year, 6 (4 male, 2 female) had completed QOLQ. The median age 63 yrs (range: 32-90); median lesions/patient was 2(1-16).
A prospective evaluation using QOL questionnaires (QOLQ) at 3, 6, and year post-treatment. Mean total tumor volume was 2.03 cc (0.003-42), median KPS was 80 (30-100). 47 patients underwent GKRS alone (surgery or not) (Group IA-C); 7 GKRS then WBRT + surgery (Group II); 17 WBRT +GKRS (surgery or not) (Group IIIA, B). Addition of WBRT, chemotherapy, pre-GK KPS, number of lesions, maximum size and volume were analyzed for QOL effect.
The results were submitted as a table that is impossible to format for the abstract.
This is a retrospective study.
Group IA does better but declines at a year; Group IB has better QOL. In Group II patients are better in first 3 months. In Group III, patients having surgery + WB +GK improve while WB +GK decline.
Clearly, a larger patient population and more follow-up are needed.
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