A Prospective Analysis Of Quality Of Life Outcomes After Gamma Knife Radiosurgery For Brain Metastases

Emily Ducharme1, Inga S. Grills1, Sabine Macina1, Michelle Manders1, Daniela Greto1, A. H. Maitz1, Daniel Pieper1, Peter Chen1, Ricky Olson1, Michelle Wallace.1

1William Beaumont Hospital, Royal Oak, USA

Keywords: brain metastasis, quality of life, gamma knife, outcome, radiosurgery

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     Evaluate the impact of Gamma Knife Radiosurgery (GKRS) on Quality of Life (QOL) using standardized questionnaire before and after GKRS correlating QOL with treatment characteristics.
     Brain metastases in 319 patients treated with GKRS alone or combined with whole brain radiotherapy (WBRT) (10/2008 – 10/2009) .Pre-GKRS QOLQ completed in 91 (28%) patients with 41 (45%) of those patients completing post-treatment QOLQ. At 3 months, 41 (16 male, 25 female) had completed QOLQ. At 6 months, 17 (10 male, 7 female) and at year, 6 (4 male, 2 female) had completed QOLQ. The median age 63 yrs (range: 32-90); median lesions/patient was 2(1-16).
     A prospective evaluation using QOL questionnaires (QOLQ) at 3, 6, and year post-treatment. Mean total tumor volume was 2.03 cc (0.003-42), median KPS was 80 (30-100). 47 patients underwent GKRS alone (surgery or not) (Group IA-C); 7 GKRS then WBRT + surgery (Group II); 17 WBRT +GKRS (surgery or not) (Group IIIA, B). Addition of WBRT, chemotherapy, pre-GK KPS, number of lesions, maximum size and volume were analyzed for QOL effect.
     The results were submitted as a table that is impossible to format for the abstract.
     This is a retrospective study.
     Group IA does better but declines at a year; Group IB has better QOL. In Group II patients are better in first 3 months. In Group III, patients having surgery + WB +GK improve while WB +GK decline. 
     Clearly, a larger patient population and more follow-up are needed.


Project Roles:

E. Ducharme (), I. Grills (), S. Macina (), M. Manders (), D. Greto (), A. Maitz (), D. Pieper (), P. Chen (), R. Olson (), M. Wallace. ()